UKE Microscopy Imaging Facility (DFG Research Infrastructure Portal: RI_00489)


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MINFLUX microscopy made the visualization of SARS-CoV2 virus molecules possible. (1) Confocal, (2) MINFLUX, (3) MINFLUX superimposed with EM, (4) schematic overlay with SARS-CoV2 model

Confocal microscopy III

Mouse hippocampus

GFAP (for astrocytes) / Iba-1 (microglia) / Hoechst (nucleus). Author: Prof Saez

Confocal microscopy I

Optical nerve

tiled scan

Confocal microscopy II

Heart tissue section

Super-resolution image of detyrosinated tubulin.

Detyrosinated tubulin in neurons.

left = confocal, right = STED

Super-resolution 3D dSTORM image of microtubules

Alpha-tubulin in HeLa cells.

Color-coded z-distribution.

Structured illumination microscopy (SIM)

Multicolor labeling of an eukaryotic cell.

red =actin, green = focal adhesions, blue = DAPI

Combined SD-TIRF imaging of cellular vesicles

3D reconstruction of CLN3-vesicles and lysosomes in HeLa cells.

green = CLN3-GFP, red = lysosomes

Super-resolution radial fluorescence microscopy (SRRF)

Mutli-color HeLa cells

green = F-Actin red = alpha-Tubulin gray = TOMM-20
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Dear Hamburg scientists,

I am extremely excited to announce that in the second week of October a powerful MINFLUX imaging platform will be installed at UKE .

This microscope will enable to investigate biological elementary structures with molecular resolution  i.e. (1-5) nm imaging resolution.

The microscope will be open to all Hamburg researchers and if you would like to know more please do not hesitate to contact me (a.failla{at}

Most important: In order to offer you theoretical and practical insight about  cutting edge super resolution microscopy I invite you to participate to an outstanding workshop that will take place at UKE between the 22nd and 24th of November: "Abberior STED and MINFLUX nanoscopy workshop".

Please find the workshop flyer below.

Facts are:

1) the workshop is free of charge

2) there are not limitation for attend to the theoretical part

3) only 15 places will be available for the practical sections therefore if you are interested book as soon as possible

The workshop is fully booked! 

Last but not least Abberior is bringing in during the workshop their STEDYCON their simple but powerful solution to perform STED microscopy in any lab.

You are all warm invited to contact Sandra Kostrowski from Abberior (s.kostrowski{at} and book a test section at the machine. You can do it, for example, in between two practical sections (Practical sections schedule will come soon).

You are all warmly invited to participate and please diffuse this information to everyone you think might be interested.

Finally we want to express our special thanks to the EU  that via  the European Regional Development Fund (ERDF) has financed the UKE MINFLUX imaging platform.

Best wishes

Antonio Virgilio Failla


Nanoscopy workshop2022

Open positions at Abberior Instruments

If someone of you is potentially interested to work in the industry direction microscopy, please consider the job offerings of the company Abberior (leader in super resolution optical microscopy) below.

abberior_job1.jpg abberior_job2.jpg


Leica Imaging Workshop 09.-25. Feb '22

In cooperation with Leica Microsystems and the Centre for Structural Systems Biology (CSSB) Hamburg, we invite you to attend a series of talks and product showcases featuring the STELLARIS 8 FALCON confocal and THUNDER Imager widefield systems.

Join this exciting workshop and learn how these microscopy innovations can make a difference to your research.

To participate to any event of the workshop, registration is necessary (please follow the links below), but there are no registration fees. You are all invited to participate and you can extend this invitation to anyone you think might be interested.


Wednesday 9th February, ONLINE PRESENTATION >>>> click HERE for details and registration <<<<
The experienced Leica team of advanced workflow specialists will present the innovation and application possibilities of both systems. Put your questions to their experts and discuss your application needs.


Monday 21st - Friday 25th February, LIVE PRODUCT SHOWCASE >>>> click HERE for details and registration <<<<
Come to the UKE Microscopy Facility (UMIF) for a personal demonstration and try the systems out with your own microscopy samples. 


Important!! Please send a feedback Email to Dr. Antonio Virgilio Failla (a.failla{at} if you intend to participate to the webinars and the practical tests (the latest will be necessary for reserving you time and for respecting the security regulation).


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